Alejandro Gonzalez Inarritu (AMORES PERROS) directs this staggeringly intense drama concerning three families whose lives fatefully intertwine through a series of tragic events. With jumbled chronology that jumps from one shocking event to the next in an increasingly chaotic maelstrom, 21 GRAMS is relentlessly gritty in its content and its aesthetics. The title refers to the amount of weight that a human body loses at the moment of death, but the story begs the question: How much is gained'

Paul (Sean Penn) has less than a month to live, stalled on the waiting list for a heart transplant, and his wife (Charlotte Gainsbourg) is determined to get pregnant with his child before it's too late. Meanwhile, Cristina (Naomi Watts) is a happy mother with a loving husband and two daughters but she loses her family in an instant to an unpredictable accident. Finally, Jack (Benicio Del Toro) is an ex-con and born-again Christian struggling to support his wife and two children while battling his own guilty conscience. When these three parties come together, explosively, they make each other behave in impulsive, violent, and destructive ways. 21 GRAMS takes viewers on a jolting journey through sickness, suffering, morality, revenge, and last but not least, the sometimes welcome peace of death.